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Search Results for " allosteric modulator "

20

Compounds

Cat No. Product Name Synonyms Targets
T61562 CB1R Allosteric modulator 3 cAMP , Cannabinoid Receptor
CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nicotine addiction.
T4573 Cyclothiazide GluR
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
T21747 VU0483605 GluR
VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
T22711 DCB 3,3'-dichlorobenzaldazine Others , GluR
DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the positive allosteric regulation of mGluRs with the help of ...
T26869 BMS-986122 BMS 986122 Opioid Receptor
BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...
T62016 CB1R Allosteric modulator 1
CB1R Allosteric modulator 1 (compound 11) is a potent allosteric modulator of CB1R. CB1R Allosteric modulator 1 negatively affects the functional activity of orthosteric ligands (NAM) at CB1Rs.
T9699 TAK-615 LPA Receptor
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
T61276 CB1R Allosteric modulator 2
CB1R Allosteric modulator 2 (compound 18) is a potent allosteric modulator of the CB1R receptor. It exhibits negative modulation of the functional activity of orthosteric ligands (NAM) at CB1Rs, as demonstrated in previo...
T61371 CB1R Allosteric modulator 4
CB1R Allosteric modulator 4 is an effective and positive modulator of cannabinoid type-1 (CB1R), exhibiting significant biological activity. This compound inhibits the production of cAMP and demonstrates strong β-arresti...
T28069 ML380 ML 380,ML-380 AChR
ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).
T29137 VU0453595 VU 0453595,VU-0453595 AChR
VU0453595 is a M1 positive allosteric modulator (PAM).
T8776 FEMA 4774 S9632 Others
FEMA 4774 (S9632) is a positive allosteric modulator of T1R2/T1R3. FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests
T23469 TQS 4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide AChR
TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) is a positive allosteric modulator of α7 nACh receptors.
T23524 W-84 dibromide HDMPPA AChR
W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.
T7165 Basmisanil RG1662,RO5186582 GABA Receptor
Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro...
T1884 CX516 Ampakine CX516,BDP 12,Ampalex GluR , iGluR
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
T60047 V-0219 Glucagon Receptor
V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.
T4522 SSD114 HCl GABA Receptor
SSD114 is a novel GABAB receptor positive allosteric modulator.
T22976 MFZ 10-7 Others , GluR
MFZ 10-7 is anegative allosteric modulator of the mGluR5.
T15942 MK-7622 M1 receptor modulator AChR
MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric.
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TargetMol